Drug interactions
Amphotericin b deoxycholate + Streptomycin
Severity: Major
Amphotericin b deoxycholate and Streptomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Used together, they can cause additive kidney injury, and reduced renal clearance of streptomycin can in turn raise its levels and increase ear toxicity.
What this interaction means in plain words
Amphotericin b deoxycholate and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, with impaired renal function increasing aminoglycoside accumulation and ototoxicity.
What to do
Avoid the combination when alternatives exist. If needed, monitor serum creatinine, electrolytes and streptomycin levels, and assess hearing and vestibular function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Amphotericin b deoxycholate with Streptomycin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Used together, they can cause additive kidney injury, and reduced renal clearance of streptomycin can in turn raise its levels and increase ear toxicity.
How serious is the interaction between Amphotericin b deoxycholate and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when alternatives exist. If needed, monitor serum creatinine, electrolytes and streptomycin levels, and assess hearing and vestibular function.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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