Drug interactions
Bacitracin + Streptomycin
Severity: Major
Bacitracin and Streptomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic bacitracin is nephrotoxic, and streptomycin can cause both kidney injury and ototoxicity. Together they raise the risk of renal damage and hearing or vestibular injury.
What this interaction means in plain words
Bacitracin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin belongs to Miscellaneous; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity and ototoxicity from two agents that injure renal tubular cells and the inner ear.
What to do
Avoid concurrent use. If unavoidable, monitor serum creatinine, urine output, drug levels and hearing or vestibular function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Streptomycin
Other interactions of Bacitracin
- Bacitracin + Cidofovir Contraindicated
- Adefovir + Bacitracin Major
- Aldesleukin + Bacitracin Major
- Amikacin + Bacitracin Major
- Bacitracin + Carboplatin Major
- Bacitracin + Cisplatin Major
Frequently asked questions
Can I take Bacitracin with Streptomycin?
MediHelp rates the interaction as major. Bacitracin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic bacitracin is nephrotoxic, and streptomycin can cause both kidney injury and ototoxicity. Together they raise the risk of renal damage and hearing or vestibular injury.
How serious is the interaction between Bacitracin and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If unavoidable, monitor serum creatinine, urine output, drug levels and hearing or vestibular function closely.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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