Drug interactions
Amphotericin b deoxycholate + Valganciclovir
Severity: Moderate
Amphotericin b deoxycholate and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B deoxycholate is nephrotoxic, and reduced renal function increases ganciclovir exposure and thereby the risk of myelosuppression. Both drugs can also contribute to cytopenias.
What this interaction means in plain words
Amphotericin b deoxycholate and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amphotericin nephrotoxicity reducing ganciclovir clearance, plus additive myelosuppression.
What to do
Monitor serum creatinine, electrolytes and complete blood counts frequently, and adjust valganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b deoxycholate and Valganciclovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Valganciclovir
Frequently asked questions
Can I take Amphotericin b deoxycholate with Valganciclovir?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B deoxycholate is nephrotoxic, and reduced renal function increases ganciclovir exposure and thereby the risk of myelosuppression. Both drugs can also contribute to cytopenias.
How serious is the interaction between Amphotericin b deoxycholate and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes and complete blood counts frequently, and adjust valganciclovir dose to creatinine clearance.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
