Drug interactions
Ampicillin-sulbactam + Cholera vaccine
Severity: Moderate
Ampicillin-sulbactam and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live attenuated cholera vaccine contains a living bacterial strain that antibiotics can kill. Recent antibiotic exposure may therefore reduce vaccine take and protection.
What this interaction means in plain words
Ampicillin-sulbactam and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain impairs colonisation and immune response.
What to do
Do not give the vaccine within 14 days after systemic antibiotics. Delay vaccination until the interval has passed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ampicillin-sulbactam
Frequently asked questions
Can I take Ampicillin-sulbactam with Cholera vaccine?
MediHelp rates the interaction as moderate. Ampicillin-sulbactam and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live attenuated cholera vaccine contains a living bacterial strain that antibiotics can kill. Recent antibiotic exposure may therefore reduce vaccine take and protection.
How serious is the interaction between Ampicillin-sulbactam and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine within 14 days after systemic antibiotics. Delay vaccination until the interval has passed.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
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