Drug interactions
Amyl nitrite + Lofexidine
Severity: Moderate
Amyl nitrite and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amyl nitrite is a potent vasodilator and lofexidine lowers blood pressure and heart rate. Together they may cause marked hypotension, syncope and reflex or excessive bradycardia.
What this interaction means in plain words
Amyl nitrite and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from vasodilation and central alpha-2 agonism.
What to do
Monitor blood pressure and heart rate and ensure the patient is seated or supine when the nitrite is used. Avoid use in patients who are already hypotensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Amyl nitrite with Lofexidine?
MediHelp rates the interaction as moderate. Amyl nitrite and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amyl nitrite is a potent vasodilator and lofexidine lowers blood pressure and heart rate. Together they may cause marked hypotension, syncope and reflex or excessive bradycardia.
How serious is the interaction between Amyl nitrite and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and ensure the patient is seated or supine when the nitrite is used. Avoid use in patients who are already hypotensive.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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