Drug interactions
Acetylsalicylic acid + Anagrelide
Severity: Moderate
Acetylsalicylic acid and Anagrelide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide inhibits platelet aggregation, and with aspirin the bleeding risk is increased, particularly gastrointestinal bleeding. The combination is sometimes used in essential thrombocythemia but requires care.
What this interaction means in plain words
Acetylsalicylic acid and Anagrelide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Anagrelide belongs to Cardiovascular.
Why it happens
Additive antiplatelet effects through different pathways (PDE3 inhibition and COX-1 inhibition).
What to do
Monitor for bleeding and platelet counts. Consider gastroprotection in patients at GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Acetylsalicylic acid with Anagrelide?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Anagrelide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide inhibits platelet aggregation, and with aspirin the bleeding risk is increased, particularly gastrointestinal bleeding. The combination is sometimes used in essential thrombocythemia but requires care.
How serious is the interaction between Acetylsalicylic acid and Anagrelide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and platelet counts. Consider gastroprotection in patients at GI risk.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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