Drug interactions
Anagrelide + Panobinostat
Severity: Contraindicated
Anagrelide and Panobinostat: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat markedly prolongs the QT interval, and its labeling advises against use with other QT-prolonging drugs. Adding anagrelide raises the risk of torsades de pointes and sudden death.
What this interaction means in plain words
Anagrelide and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Anagrelide belongs to Cardiovascular; Panobinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Do not combine; select an alternative to anagrelide during panobinostat therapy. Monitor ECG and electrolytes per panobinostat labeling.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Anagrelide
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
- Amiodarone + Anagrelide Major
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Moxifloxacin + Panobinostat Contraindicated
Frequently asked questions
Can I take Anagrelide with Panobinostat?
MediHelp rates the interaction as contraindicated. Anagrelide and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Panobinostat markedly prolongs the QT interval, and its labeling advises against use with other QT-prolonging drugs. Adding anagrelide raises the risk of torsades de pointes and sudden death.
How serious is the interaction between Anagrelide and Panobinostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select an alternative to anagrelide during panobinostat therapy. Monitor ECG and electrolytes per panobinostat labeling.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Anagrelide page.
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