Drug interactions
Anakinra + Antithymocyte globulin rabbit
Severity: Major
Anakinra and Antithymocyte globulin rabbit: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anakinra given with profound T-cell depleting therapy may add to infection risk. Anakinra labeling advises against combining it with other immunosuppressive biologics because of the infection concern.
What this interaction means in plain words
Anakinra and Antithymocyte globulin rabbit can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from IL-1 blockade plus polyclonal T-cell depletion.
What to do
Avoid concurrent use unless clearly necessary; if combined, monitor for bacterial, viral and opportunistic infections and consider antimicrobial prophylaxis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Frequently asked questions
Can I take Anakinra with Antithymocyte globulin rabbit?
MediHelp rates the interaction as major. Anakinra and Antithymocyte globulin rabbit can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anakinra given with profound T-cell depleting therapy may add to infection risk. Anakinra labeling advises against combining it with other immunosuppressive biologics because of the infection concern.
How serious is the interaction between Anakinra and Antithymocyte globulin rabbit?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless clearly necessary; if combined, monitor for bacterial, viral and opportunistic infections and consider antimicrobial prophylaxis.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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