Drug reference
anakinra
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (TNF-alpha Inhibitors)
Mechanism of action
Both IL-1α and IL-1β act through IL-1 receptor 1 to stimulate the production of inflammatory cytokines and TNFα that lead to the inflammatory cascade. The inflammasome is a complex of distinct proteins which together convert inactive prointerleukin-1β to active IL-1β.
Common side effects
- Injection-site reaction
- Headache
- Nausea
- Diarrhea
Contraindications
- Hypersensitivity to drug or excipients, including E coli-derived proteins
Known interactions (5)
- anakinra + measles mumps and rubella vaccine Contraindicated
- abatacept + anakinra Major
- anakinra + hepatitis a vaccine inactivated Moderate
- anakinra + lenalidomide Moderate
- anakinra + pneumococcal vaccine 13-valent Moderate
Related conditions
Frequently asked questions
What drug class is anakinra?
anakinra belongs to: Musculoskeletal.
How does anakinra work?
Both IL-1α and IL-1β act through IL-1 receptor 1 to stimulate the production of inflammatory cytokines and TNFα that lead to the inflammatory cascade. The inflammasome is a complex of distinct proteins which together convert inactive prointerleukin-1β to active IL-1β.
What are the common side effects of anakinra?
Injection-site reaction, Headache, Nausea, Diarrhea
Which drugs interact with anakinra?
measles mumps and rubella vaccine, abatacept, hepatitis a vaccine inactivated, lenalidomide, pneumococcal vaccine 13-valent
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