Drug interactions
Anakinra + Belimumab
Severity: Moderate
Anakinra and Belimumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs modulate the immune system, and combined use may raise the likelihood of serious infections. Combination experience is limited.
What this interaction means in plain words
Anakinra and Belimumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anakinra belongs to Musculoskeletal; Belimumab belongs to Miscellaneous.
Why it happens
Additive immunosuppression via IL-1 blockade and BLyS inhibition of B-cell survival.
What to do
Monitor for signs of infection and treat promptly. Reassess the need for both agents regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Other interactions of Belimumab
- Belimumab + Measles mumps and rubella vaccine Major
- Abatacept + Belimumab Moderate
- Adalimumab + Belimumab Moderate
- Anti-thymocyte + Belimumab Moderate
- Belimumab + Denosumab Moderate
- Belimumab + Fingolimod Moderate
Frequently asked questions
Can I take Anakinra with Belimumab?
MediHelp rates the interaction as moderate. Anakinra and Belimumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs modulate the immune system, and combined use may raise the likelihood of serious infections. Combination experience is limited.
How serious is the interaction between Anakinra and Belimumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and treat promptly. Reassess the need for both agents regularly.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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