Drug interactions
Anakinra + Muromonab cd3
Severity: Major
Anakinra and Muromonab cd3: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Muromonab-CD3 causes profound T-cell depletion, and adding anakinra may further increase the risk of serious and opportunistic infections. Muromonab-CD3 has been withdrawn from the market, so this combination is rarely encountered.
What this interaction means in plain words
Anakinra and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from IL-1 blockade and anti-CD3 T-cell depletion.
What to do
Avoid the combination; if historical or compassionate use occurs, monitor closely for infection and consider prophylaxis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Frequently asked questions
Can I take Anakinra with Muromonab cd3?
MediHelp rates the interaction as major. Anakinra and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Muromonab-CD3 causes profound T-cell depletion, and adding anakinra may further increase the risk of serious and opportunistic infections. Muromonab-CD3 has been withdrawn from the market, so this combination is rarely encountered.
How serious is the interaction between Anakinra and Muromonab cd3?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if historical or compassionate use occurs, monitor closely for infection and consider prophylaxis.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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