Drug interactions
Anakinra + Ofatumumab sc
Severity: Moderate
Anakinra and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents impair immune function, so concurrent use may increase the risk of infections. Ofatumumab causes prolonged B-cell depletion, adding to the overall immunosuppressive load.
What this interaction means in plain words
Anakinra and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression via IL-1 receptor antagonism and anti-CD20 B-cell depletion.
What to do
Monitor for infection and consider immunoglobulin levels during ofatumumab therapy. Reassess the need for combined therapy regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Frequently asked questions
Can I take Anakinra with Ofatumumab sc?
MediHelp rates the interaction as moderate. Anakinra and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents impair immune function, so concurrent use may increase the risk of infections. Ofatumumab causes prolonged B-cell depletion, adding to the overall immunosuppressive load.
How serious is the interaction between Anakinra and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and consider immunoglobulin levels during ofatumumab therapy. Reassess the need for combined therapy regularly.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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