Drug interactions
Anakinra + Pneumococcal vaccine polyvalent
Severity: Minor
Anakinra and Pneumococcal vaccine polyvalent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anakinra blocks interleukin-1 signalling and may modestly dampen the immune response to vaccines. Inactivated pneumococcal vaccines can be given, but protection may be lower than expected. Labeling does not prohibit inactivated vaccines.
What this interaction means in plain words
Anakinra and Pneumococcal vaccine polyvalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic: IL-1 receptor blockade may modestly reduce vaccine-induced antibody response.
What to do
Inactivated pneumococcal vaccine can be given during anakinra therapy; ideally vaccinate before starting treatment. Consider checking antibody titres where protection is critical.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Frequently asked questions
Can I take Anakinra with Pneumococcal vaccine polyvalent?
MediHelp rates the interaction as minor. Anakinra and Pneumococcal vaccine polyvalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anakinra blocks interleukin-1 signalling and may modestly dampen the immune response to vaccines. Inactivated pneumococcal vaccines can be given, but protection may be lower than expected. Labeling does not prohibit inactivated vaccines.
How serious is the interaction between Anakinra and Pneumococcal vaccine polyvalent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inactivated pneumococcal vaccine can be given during anakinra therapy; ideally vaccinate before starting treatment. Consider checking antibody titres where protection is critical.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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