Drug interactions
Anakinra + Rabies vaccine
Severity: Moderate
Anakinra and Rabies vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anakinra may blunt antibody responses to non-live vaccines such as rabies vaccine. This matters most for pre- or post-exposure prophylaxis, where adequate immunity is essential. The vaccine is inactivated and is not contraindicated.
What this interaction means in plain words
Anakinra and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic: IL-1 blockade may reduce the development of vaccine-induced active immunity.
What to do
Do not withhold post-exposure rabies prophylaxis; give the full vaccine course with immune globulin as indicated. Check rabies neutralising antibody titres after vaccination to confirm response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Frequently asked questions
Can I take Anakinra with Rabies vaccine?
MediHelp rates the interaction as moderate. Anakinra and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anakinra may blunt antibody responses to non-live vaccines such as rabies vaccine. This matters most for pre- or post-exposure prophylaxis, where adequate immunity is essential. The vaccine is inactivated and is not contraindicated.
How serious is the interaction between Anakinra and Rabies vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold post-exposure rabies prophylaxis; give the full vaccine course with immune globulin as indicated. Check rabies neutralising antibody titres after vaccination to confirm response.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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