Drug interactions
Anakinra + Rubella vaccine
Severity: Major
Anakinra and Rubella vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rubella vaccine is live attenuated, and anakinra-related immunosuppression may allow vaccine virus to replicate excessively. Vaccine efficacy may also be reduced. Labeling advises against live vaccines with anakinra.
What this interaction means in plain words
Anakinra and Rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic: IL-1 blockade impairs immune control of live attenuated virus.
What to do
Avoid giving rubella vaccine during anakinra therapy. Vaccinate before starting treatment when feasible, and seek specialist advice about timing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Frequently asked questions
Can I take Anakinra with Rubella vaccine?
MediHelp rates the interaction as major. Anakinra and Rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rubella vaccine is live attenuated, and anakinra-related immunosuppression may allow vaccine virus to replicate excessively. Vaccine efficacy may also be reduced. Labeling advises against live vaccines with anakinra.
How serious is the interaction between Anakinra and Rubella vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving rubella vaccine during anakinra therapy. Vaccinate before starting treatment when feasible, and seek specialist advice about timing.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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