Drug interactions
Anakinra + Thalidomide
Severity: Moderate
Anakinra and Thalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents affect immune function, and using them together may add to the risk of infection. The combination has not been well characterized, and the interaction is largely predicted.
What this interaction means in plain words
Anakinra and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anakinra belongs to Musculoskeletal; Thalidomide belongs to Miscellaneous.
Why it happens
Additive immunomodulatory effects; interleukin-1 blockade plus thalidomide's immunomodulation may increase infection susceptibility.
What to do
Monitor closely for signs of infection and treat promptly; reassess the need for both drugs if serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Other interactions of Thalidomide
Frequently asked questions
Can I take Anakinra with Thalidomide?
MediHelp rates the interaction as moderate. Anakinra and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents affect immune function, and using them together may add to the risk of infection. The combination has not been well characterized, and the interaction is largely predicted.
How serious is the interaction between Anakinra and Thalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for signs of infection and treat promptly; reassess the need for both drugs if serious infection develops.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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