Drug interactions
Anakinra + Yellow fever vaccine
Severity: Major
Anakinra and Yellow fever vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yellow fever vaccine is live attenuated and can cause serious viscerotropic or neurotropic disease in immunosuppressed patients. Anakinra may increase this risk and reduce efficacy.
What this interaction means in plain words
Anakinra and Yellow fever vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic: IL-1 blockade impairs control of live vaccine virus replication.
What to do
Avoid vaccination during anakinra treatment; if travel to an endemic area is unavoidable, seek specialist advice, and consider a medical exemption letter.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Frequently asked questions
Can I take Anakinra with Yellow fever vaccine?
MediHelp rates the interaction as major. Anakinra and Yellow fever vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yellow fever vaccine is live attenuated and can cause serious viscerotropic or neurotropic disease in immunosuppressed patients. Anakinra may increase this risk and reduce efficacy.
How serious is the interaction between Anakinra and Yellow fever vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination during anakinra treatment; if travel to an endemic area is unavoidable, seek specialist advice, and consider a medical exemption letter.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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