Drug interactions
Anakinra + Zoster vaccine recombinant
Severity: Minor
Anakinra and Zoster vaccine recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from anakinra may blunt the antibody and T-cell response to the recombinant zoster vaccine, reducing protection. The vaccine is non-live, so there is no risk of vaccine-strain infection.
What this interaction means in plain words
Anakinra and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic dampening of the immune response to vaccination by IL-1 blockade.
What to do
Vaccination can proceed and should not be withheld; where practical, give the vaccine before starting immunosuppression or at a time of lower immunosuppression. Do not rely on a single dose response in high-risk patients without completing the schedule.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Frequently asked questions
Can I take Anakinra with Zoster vaccine recombinant?
MediHelp rates the interaction as minor. Anakinra and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Immunosuppression from anakinra may blunt the antibody and T-cell response to the recombinant zoster vaccine, reducing protection. The vaccine is non-live, so there is no risk of vaccine-strain infection.
How serious is the interaction between Anakinra and Zoster vaccine recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccination can proceed and should not be withheld; where practical, give the vaccine before starting immunosuppression or at a time of lower immunosuppression. Do not rely on a single dose response in high-risk patients without completing the schedule.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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