Drug interactions
Anthrax vaccine + Deflazacort
Severity: Moderate
Anthrax vaccine and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can blunt the immune response to vaccines, potentially reducing protection from anthrax vaccination. The anthrax vaccine is non-live, so the infection risk seen with live vaccines does not apply, and the issue is reduced efficacy only.
What this interaction means in plain words
Anthrax vaccine and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression by corticosteroid reduces antibody response to vaccination.
What to do
If possible, complete vaccination at least 2 weeks before starting deflazacort or defer vaccination until immunosuppressive dosing is reduced. When given during therapy, consider checking antibody response or repeating a dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Anthrax vaccine with Deflazacort?
MediHelp rates the interaction as moderate. Anthrax vaccine and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can blunt the immune response to vaccines, potentially reducing protection from anthrax vaccination. The anthrax vaccine is non-live, so the infection risk seen with live vaccines does not apply, and the issue is reduced efficacy only.
How serious is the interaction between Anthrax vaccine and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If possible, complete vaccination at least 2 weeks before starting deflazacort or defer vaccination until immunosuppressive dosing is reduced. When given during therapy, consider checking antibody response or repeating a dose.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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