Drug interactions
Deflazacort + Measles mumps rubella and varicella vaccine live
Severity: Contraindicated
Deflazacort and Measles mumps rubella and varicella vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This live vaccine includes varicella virus along with MMR, and replication may be uncontrolled in patients immunosuppressed by deflazacort. This can cause disseminated vaccine-strain disease and a poor immune response.
What this interaction means in plain words
Deflazacort and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Glucocorticoid immunosuppression impairs control of live attenuated viruses and reduces vaccine immunogenicity.
What to do
Do not administer during immunosuppressive steroid therapy; schedule before starting steroids or after the labeled washout. Use post-exposure measures instead if exposed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles vaccine Contraindicated
Frequently asked questions
Can I take Deflazacort with Measles mumps rubella and varicella vaccine live?
MediHelp rates the interaction as contraindicated. Deflazacort and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This live vaccine includes varicella virus along with MMR, and replication may be uncontrolled in patients immunosuppressed by deflazacort. This can cause disseminated vaccine-strain disease and a poor immune response.
How serious is the interaction between Deflazacort and Measles mumps rubella and varicella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not administer during immunosuppressive steroid therapy; schedule before starting steroids or after the labeled washout. Use post-exposure measures instead if exposed.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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