Drug interactions
Antipyrine + Desogestrel-ethinyl estradiol
Severity: Minor
Antipyrine and Desogestrel-ethinyl estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol can reduce clearance of antipyrine, which is a probe drug for hepatic oxidative metabolism. This is mainly relevant to metabolic testing rather than patient care.
What this interaction means in plain words
Antipyrine and Desogestrel-ethinyl estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ethinyl estradiol inhibits hepatic oxidative metabolism of antipyrine, including CYP1A2.
What to do
No clinical action is usually required. Account for the effect when interpreting antipyrine clearance tests.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Antipyrine with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as minor. Antipyrine and Desogestrel-ethinyl estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol can reduce clearance of antipyrine, which is a probe drug for hepatic oxidative metabolism. This is mainly relevant to metabolic testing rather than patient care.
How serious is the interaction between Antipyrine and Desogestrel-ethinyl estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No clinical action is usually required. Account for the effect when interpreting antipyrine clearance tests.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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