Drug interactions
Antipyrine + Propranolol
Severity: Minor
Antipyrine and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol can reduce the clearance of antipyrine, raising its levels and prolonging its half-life. The effect is mainly a pharmacokinetic finding with limited clinical consequence.
What this interaction means in plain words
Antipyrine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Propranolol reduces hepatic blood flow and may inhibit hepatic oxidative metabolism of antipyrine.
What to do
No routine action is needed. Be aware of reduced antipyrine clearance if it is used as a metabolic probe.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Antipyrine with Propranolol?
MediHelp rates the interaction as minor. Antipyrine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol can reduce the clearance of antipyrine, raising its levels and prolonging its half-life. The effect is mainly a pharmacokinetic finding with limited clinical consequence.
How serious is the interaction between Antipyrine and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Be aware of reduced antipyrine clearance if it is used as a metabolic probe.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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