Drug interactions
Antithrombin alfa + Deflazacort
Severity: Minor
Antithrombin alfa and Deflazacort: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter coagulation and vascular integrity and may modify the effect of anticoagulant therapy in either direction. Antithrombin enhances heparin-type anticoagulation, so bleeding risk or reduced efficacy may occur. The effect is unpredictable and usually modest.
What this interaction means in plain words
Antithrombin alfa and Deflazacort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Corticosteroids have variable effects on coagulability and vascular fragility; no defined direct interaction with antithrombin.
What to do
Monitor coagulation parameters such as aPTT or anti-Xa as appropriate to the concurrent anticoagulant, and watch for bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Antithrombin alfa with Deflazacort?
MediHelp rates the interaction as minor. Antithrombin alfa and Deflazacort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids can alter coagulation and vascular integrity and may modify the effect of anticoagulant therapy in either direction. Antithrombin enhances heparin-type anticoagulation, so bleeding risk or reduced efficacy may occur. The effect is unpredictable and usually modest.
How serious is the interaction between Antithrombin alfa and Deflazacort?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor coagulation parameters such as aPTT or anti-Xa as appropriate to the concurrent anticoagulant, and watch for bleeding.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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