Drug interactions
Antithrombin alfa + Flurbiprofen
Severity: Moderate
Antithrombin alfa and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin alfa potentiates heparin-type anticoagulation, and flurbiprofen impairs platelet function and can cause gastrointestinal mucosal injury. Together they increase the likelihood of bleeding.
What this interaction means in plain words
Antithrombin alfa and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: anticoagulant effect plus NSAID antiplatelet action.
What to do
Monitor for bleeding and relevant coagulation parameters; avoid the NSAID where an alternative analgesic is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Antithrombin alfa with Flurbiprofen?
MediHelp rates the interaction as moderate. Antithrombin alfa and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin alfa potentiates heparin-type anticoagulation, and flurbiprofen impairs platelet function and can cause gastrointestinal mucosal injury. Together they increase the likelihood of bleeding.
How serious is the interaction between Antithrombin alfa and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and relevant coagulation parameters; avoid the NSAID where an alternative analgesic is suitable.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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