Drug interactions
Antithrombin alfa + Meloxicam
Severity: Moderate
Antithrombin alfa and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin alfa potentiates heparin-type anticoagulation, while meloxicam impairs platelet function and can injure the gastric mucosa. Together they raise the risk of bleeding, particularly gastrointestinal bleeding.
What this interaction means in plain words
Antithrombin alfa and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects: enhanced coagulation inhibition plus NSAID antiplatelet effect and mucosal injury.
What to do
Monitor for signs of bleeding and coagulation parameters appropriate to the anticoagulant regimen. Avoid the NSAID where an alternative analgesic is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Antithrombin alfa with Meloxicam?
MediHelp rates the interaction as moderate. Antithrombin alfa and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin alfa potentiates heparin-type anticoagulation, while meloxicam impairs platelet function and can injure the gastric mucosa. Together they raise the risk of bleeding, particularly gastrointestinal bleeding.
How serious is the interaction between Antithrombin alfa and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and coagulation parameters appropriate to the anticoagulant regimen. Avoid the NSAID where an alternative analgesic is suitable.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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