Drug interactions
Antithrombin alfa + Naproxen
Severity: Moderate
Antithrombin alfa and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates heparin-type anticoagulation, and naproxen impairs platelet function and can injure the gastric mucosa. Together the risk of bleeding, especially gastrointestinal, is increased.
What this interaction means in plain words
Antithrombin alfa and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: antithrombin inhibits coagulation factors while naproxen reversibly inhibits platelet thromboxane production.
What to do
Avoid NSAIDs where possible during antithrombin therapy, or monitor for bleeding and hemoglobin. Consider a non-NSAID analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Antithrombin alfa with Naproxen?
MediHelp rates the interaction as moderate. Antithrombin alfa and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin potentiates heparin-type anticoagulation, and naproxen impairs platelet function and can injure the gastric mucosa. Together the risk of bleeding, especially gastrointestinal, is increased.
How serious is the interaction between Antithrombin alfa and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible during antithrombin therapy, or monitor for bleeding and hemoglobin. Consider a non-NSAID analgesic such as paracetamol.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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