Drug reference
naproxen
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (NSAIDs)
Mechanism of action
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase (COX) isoenzymes, COX-1 and COX-2. May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity.
Common side effects
- Constipation
- Dizziness
- Drowsiness
- Headache
- Abdominal pain
Contraindications
- Absolute: Aspirin allergy; perioperative pain in setting of coronary artery bypass graft (CABG) surgery Relative: Bleeding disorders, delayed esophageal transit, hepatic disease, peptic ulcer, renal impairment, stomatitis, late pregnancy (may cause premature closure of ductus arteriosus)
Known interactions (2)
- Celecoxib + naproxen Major
- Ciprofloxacin + naproxen Moderate
Related conditions
Frequently asked questions
What drug class is naproxen?
naproxen belongs to: Musculoskeletal.
How does naproxen work?
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase (COX) isoenzymes, COX-1 and COX-2. May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity.
What are the common side effects of naproxen?
Constipation, Dizziness, Drowsiness, Headache, Abdominal pain
Which drugs interact with naproxen?
Celecoxib, Ciprofloxacin
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