Drug interactions
Antithrombin alfa + Piperacillin
Severity: Moderate
Antithrombin alfa and Piperacillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piperacillin can impair platelet function and may add to bleeding risk in patients receiving antithrombin, which is used with heparin. The interaction is mainly theoretical and may be modest.
What this interaction means in plain words
Antithrombin alfa and Piperacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
High-dose piperacillin impairs platelet aggregation, adding to antithrombin-enhanced anticoagulation.
What to do
Monitor for bleeding and coagulation parameters such as aPTT or anti-Xa during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Acetylsalicylic acid + Piperacillin Moderate
- Amikacin + Piperacillin Moderate
- Antithrombin iii + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
- Avelumab + Piperacillin Moderate
Frequently asked questions
Can I take Antithrombin alfa with Piperacillin?
MediHelp rates the interaction as moderate. Antithrombin alfa and Piperacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piperacillin can impair platelet function and may add to bleeding risk in patients receiving antithrombin, which is used with heparin. The interaction is mainly theoretical and may be modest.
How serious is the interaction between Antithrombin alfa and Piperacillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters such as aPTT or anti-Xa during co-therapy.
What other medicines interact with Piperacillin?
MediHelp also lists interactions of Piperacillin with, for example, Vancomycin, Acetylsalicylic acid, Amikacin. The full list is on the Piperacillin page.
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