Drug interactions
Antithrombin iii + Piperacillin
Severity: Moderate
Antithrombin iii and Piperacillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piperacillin can impair platelet function and may add to bleeding risk in patients receiving antithrombin. The interaction is mainly theoretical.
What this interaction means in plain words
Antithrombin iii and Piperacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
High-dose piperacillin impairs platelet aggregation, adding to antithrombin-enhanced anticoagulation.
What to do
Monitor for bleeding and coagulation parameters during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Acetylsalicylic acid + Piperacillin Moderate
- Amikacin + Piperacillin Moderate
- Antithrombin alfa + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
- Avelumab + Piperacillin Moderate
Frequently asked questions
Can I take Antithrombin iii with Piperacillin?
MediHelp rates the interaction as moderate. Antithrombin iii and Piperacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piperacillin can impair platelet function and may add to bleeding risk in patients receiving antithrombin. The interaction is mainly theoretical.
How serious is the interaction between Antithrombin iii and Piperacillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters during co-therapy.
What other medicines interact with Piperacillin?
MediHelp also lists interactions of Piperacillin with, for example, Vancomycin, Acetylsalicylic acid, Amikacin. The full list is on the Piperacillin page.
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