Drug interactions
Antithrombin iii + Bazedoxifene-conjugated estrogens
Severity: Major
Antithrombin iii and Bazedoxifene-conjugated estrogens: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III is given to patients with a thrombotic tendency from antithrombin deficiency. Estrogen-containing therapy increases clotting risk and may offset anticoagulant protection.
What this interaction means in plain words
Antithrombin iii and Bazedoxifene-conjugated estrogens can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Estrogens increase procoagulant factors and venous thrombosis risk, opposing antithrombin's anticoagulant effect.
What to do
Avoid the estrogen-bazedoxifene product in patients needing antithrombin therapy. Use non-hormonal options for menopausal symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
- Bazedoxifene-conjugated estrogens + Dalteparin Major
Frequently asked questions
Can I take Antithrombin iii with Bazedoxifene-conjugated estrogens?
MediHelp rates the interaction as major. Antithrombin iii and Bazedoxifene-conjugated estrogens can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antithrombin III is given to patients with a thrombotic tendency from antithrombin deficiency. Estrogen-containing therapy increases clotting risk and may offset anticoagulant protection.
How serious is the interaction between Antithrombin iii and Bazedoxifene-conjugated estrogens?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the estrogen-bazedoxifene product in patients needing antithrombin therapy. Use non-hormonal options for menopausal symptoms.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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