Drug interactions
Bazedoxifene-conjugated estrogens + Ospemifene
Severity: Contraindicated
Bazedoxifene-conjugated estrogens and Ospemifene: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are estrogen agonist/antagonist agents with estrogenic effects on the endometrium and venous thromboembolism risk. Combining them adds duplicate therapy and additive risk of thromboembolic events and endometrial effects without benefit.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Ospemifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Ospemifene belongs to Endocrine.
Why it happens
Additive pharmacodynamic estrogen-receptor modulation with duplicated prothrombotic and endometrial effects.
What to do
Do not use together; choose one agent for menopausal symptoms.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
- Bazedoxifene-conjugated estrogens + Dalteparin Major
Other interactions of Ospemifene
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
- Ospemifene + Rifampicin Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Ospemifene?
MediHelp rates the interaction as contraindicated. Bazedoxifene-conjugated estrogens and Ospemifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are estrogen agonist/antagonist agents with estrogenic effects on the endometrium and venous thromboembolism risk. Combining them adds duplicate therapy and additive risk of thromboembolic events and endometrial effects without benefit.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Ospemifene?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose one agent for menopausal symptoms.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Antithrombin alfa, Antithrombin iii. The full list is on the Bazedoxifene-conjugated estrogens page.
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