Drug interactions
Antithrombin iii + Dabigatran etexilate
Severity: Major
Antithrombin iii and Dabigatran etexilate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III supplementation increases the activity of the body's natural thrombin inhibition, which adds to the direct thrombin inhibition of dabigatran. The combination raises the risk of major bleeding.
What this interaction means in plain words
Antithrombin iii and Dabigatran etexilate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive anticoagulation from enhanced antithrombin-mediated and direct thrombin inhibition.
What to do
Avoid combining where possible; if antithrombin is required, hold dabigatran and bridge with a shorter-acting anticoagulant. Monitor for bleeding and coagulation parameters if both must be given.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Antithrombin iii with Dabigatran etexilate?
MediHelp rates the interaction as major. Antithrombin iii and Dabigatran etexilate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antithrombin III supplementation increases the activity of the body's natural thrombin inhibition, which adds to the direct thrombin inhibition of dabigatran. The combination raises the risk of major bleeding.
How serious is the interaction between Antithrombin iii and Dabigatran etexilate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if antithrombin is required, hold dabigatran and bridge with a shorter-acting anticoagulant. Monitor for bleeding and coagulation parameters if both must be given.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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