Drug interactions
Antithrombin iii + Flurbiprofen
Severity: Moderate
Antithrombin iii and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III concentrates enhance anticoagulation, particularly with heparin, while flurbiprofen inhibits platelet aggregation and irritates the gastric mucosa. The combination raises the risk of bleeding.
What this interaction means in plain words
Antithrombin iii and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment from anticoagulant activity and NSAID antiplatelet effects.
What to do
Monitor for bleeding and coagulation parameters; prefer a non-NSAID analgesic such as paracetamol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Antithrombin iii with Flurbiprofen?
MediHelp rates the interaction as moderate. Antithrombin iii and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III concentrates enhance anticoagulation, particularly with heparin, while flurbiprofen inhibits platelet aggregation and irritates the gastric mucosa. The combination raises the risk of bleeding.
How serious is the interaction between Antithrombin iii and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters; prefer a non-NSAID analgesic such as paracetamol where possible.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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