Drug interactions
Antithrombin iii + Ibuprofen
Severity: Moderate
Antithrombin iii and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances inhibition of thrombin and factor Xa, and ibuprofen impairs platelet function and can cause GI bleeding. Combined use raises bleeding risk.
What this interaction means in plain words
Antithrombin iii and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects: antithrombin-mediated inhibition of coagulation factors plus NSAID platelet inhibition.
What to do
Monitor for bleeding and coagulation parameters, and avoid ibuprofen where possible in favor of paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Antithrombin iii with Ibuprofen?
MediHelp rates the interaction as moderate. Antithrombin iii and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances inhibition of thrombin and factor Xa, and ibuprofen impairs platelet function and can cause GI bleeding. Combined use raises bleeding risk.
How serious is the interaction between Antithrombin iii and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters, and avoid ibuprofen where possible in favor of paracetamol.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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