Drug interactions
Antithrombin iii + Meclofenamic acid
Severity: Moderate
Antithrombin iii and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances inhibition of thrombin and factor Xa, while meclofenamate impairs platelet function and can injure the GI mucosa. The combination raises bleeding risk.
What this interaction means in plain words
Antithrombin iii and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: anticoagulant effect plus NSAID-induced platelet inhibition.
What to do
Monitor for bleeding and coagulation tests; prefer a non-NSAID analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Antithrombin iii with Meclofenamic acid?
MediHelp rates the interaction as moderate. Antithrombin iii and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances inhibition of thrombin and factor Xa, while meclofenamate impairs platelet function and can injure the GI mucosa. The combination raises bleeding risk.
How serious is the interaction between Antithrombin iii and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation tests; prefer a non-NSAID analgesic such as paracetamol.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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