Drug interactions
Antithrombin iii + Naproxen
Severity: Moderate
Antithrombin iii and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances inhibition of thrombin and factor Xa, while naproxen impairs platelet aggregation and irritates the gastric mucosa. The combination raises the risk of bleeding, particularly gastrointestinal.
What this interaction means in plain words
Antithrombin iii and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect of anticoagulation and NSAID-induced platelet inhibition.
What to do
Prefer paracetamol or another non-NSAID analgesic during antithrombin therapy. If coadministered, monitor for bleeding signs and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Antithrombin iii with Naproxen?
MediHelp rates the interaction as moderate. Antithrombin iii and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances inhibition of thrombin and factor Xa, while naproxen impairs platelet aggregation and irritates the gastric mucosa. The combination raises the risk of bleeding, particularly gastrointestinal.
How serious is the interaction between Antithrombin iii and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or another non-NSAID analgesic during antithrombin therapy. If coadministered, monitor for bleeding signs and hemoglobin.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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