Drug interactions
Antithrombin iii + Prednisolone
Severity: Minor
Antithrombin iii and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter coagulation and vascular integrity, so the effect of an anticoagulant may be either reduced or accompanied by more bleeding. The clinical effect with antithrombin is unpredictable and not well characterized.
What this interaction means in plain words
Antithrombin iii and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism is not firmly established; corticosteroids may affect coagulability and capillary fragility, which could change net anticoagulant effect.
What to do
Monitor antithrombin activity and coagulation parameters per the usual protocol, and watch for bleeding or thrombosis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Antithrombin iii with Prednisolone?
MediHelp rates the interaction as minor. Antithrombin iii and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids can alter coagulation and vascular integrity, so the effect of an anticoagulant may be either reduced or accompanied by more bleeding. The clinical effect with antithrombin is unpredictable and not well characterized.
How serious is the interaction between Antithrombin iii and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antithrombin activity and coagulation parameters per the usual protocol, and watch for bleeding or thrombosis.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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