Drug interactions
Antithrombin iii + Tolmetin
Severity: Moderate
Antithrombin iii and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances heparin-mediated anticoagulation, and NSAIDs such as tolmetin impair platelet function and can cause gastrointestinal bleeding. Together they may increase the risk of bleeding.
What this interaction means in plain words
Antithrombin iii and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment from enhanced anticoagulation and NSAID-induced platelet inhibition and mucosal injury.
What to do
Monitor for signs of bleeding and coagulation parameters during treatment. Avoid NSAIDs where practical in patients receiving antithrombin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Antithrombin iii with Tolmetin?
MediHelp rates the interaction as moderate. Antithrombin iii and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances heparin-mediated anticoagulation, and NSAIDs such as tolmetin impair platelet function and can cause gastrointestinal bleeding. Together they may increase the risk of bleeding.
How serious is the interaction between Antithrombin iii and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and coagulation parameters during treatment. Avoid NSAIDs where practical in patients receiving antithrombin therapy.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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