Drug interactions
Antithymocyte globulin equine + Basiliximab
Severity: Major
Antithymocyte globulin equine and Basiliximab: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are induction immunosuppressants that deplete or block T cells. Using them together increases infection and lymphoproliferative disorder risk without clear added benefit.
What this interaction means in plain words
Antithymocyte globulin equine and Basiliximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive T-cell depletion and IL-2 receptor blockade.
What to do
Use one induction agent rather than both; if combined, monitor for infection and use appropriate antimicrobial prophylaxis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Antithymocyte globulin equine with Basiliximab?
MediHelp rates the interaction as major. Antithymocyte globulin equine and Basiliximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are induction immunosuppressants that deplete or block T cells. Using them together increases infection and lymphoproliferative disorder risk without clear added benefit.
How serious is the interaction between Antithymocyte globulin equine and Basiliximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use one induction agent rather than both; if combined, monitor for infection and use appropriate antimicrobial prophylaxis.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
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