Drug interactions
Antithymocyte globulin rabbit + Cyclosporin
Severity: Moderate
Antithymocyte globulin rabbit and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress T-cell immunity, and combining them increases the risk of serious infections and lymphoproliferative disorders. They are commonly used together intentionally in transplantation.
What this interaction means in plain words
Antithymocyte globulin rabbit and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression through T-cell depletion and calcineurin inhibition.
What to do
Use only under specialist supervision with antimicrobial prophylaxis and monitoring for infection. Keep cyclosporine levels within the target range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Antithymocyte globulin rabbit with Cyclosporin?
MediHelp rates the interaction as moderate. Antithymocyte globulin rabbit and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress T-cell immunity, and combining them increases the risk of serious infections and lymphoproliferative disorders. They are commonly used together intentionally in transplantation.
How serious is the interaction between Antithymocyte globulin rabbit and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only under specialist supervision with antimicrobial prophylaxis and monitoring for infection. Keep cyclosporine levels within the target range.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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