Drug interactions
Arformoterol + Asenapine
Severity: Moderate
Arformoterol and Asenapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine prolongs the QT interval and arformoterol, a long-acting beta-2 agonist, may add to this through hypokalemia and tachycardia. The risk of arrhythmia is mainly relevant in patients with cardiac disease or other QT-prolonging drugs.
What this interaction means in plain words
Arformoterol and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Asenapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia and sympathetic stimulation.
What to do
Monitor heart rate, ECG and serum potassium in at-risk patients. Do not exceed recommended arformoterol doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Asenapine?
MediHelp rates the interaction as moderate. Arformoterol and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine prolongs the QT interval and arformoterol, a long-acting beta-2 agonist, may add to this through hypokalemia and tachycardia. The risk of arrhythmia is mainly relevant in patients with cardiac disease or other QT-prolonging drugs.
How serious is the interaction between Arformoterol and Asenapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and serum potassium in at-risk patients. Do not exceed recommended arformoterol doses.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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