Drug interactions
Arformoterol + Methadone
Severity: Moderate
Arformoterol and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone prolongs the QT interval, and long-acting beta-2 agonists such as arformoterol can cause tachycardia, hypokalemia and QT prolongation. Together they may increase the risk of ventricular arrhythmias, particularly in patients with cardiac disease.
What this interaction means in plain words
Arformoterol and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT-prolonging and hypokalemic effects of methadone and the beta-2 agonist.
What to do
Monitor ECG and serum potassium in patients with additional QT risk factors, and avoid exceeding recommended arformoterol doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Methadone?
MediHelp rates the interaction as moderate. Arformoterol and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methadone prolongs the QT interval, and long-acting beta-2 agonists such as arformoterol can cause tachycardia, hypokalemia and QT prolongation. Together they may increase the risk of ventricular arrhythmias, particularly in patients with cardiac disease.
How serious is the interaction between Arformoterol and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with additional QT risk factors, and avoid exceeding recommended arformoterol doses.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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