Drug interactions
Arformoterol + Nilotinib
Severity: Moderate
Arformoterol and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib has a boxed warning for QT prolongation and sudden death. Arformoterol, a long-acting beta-agonist, can prolong the QTc and lower potassium, which could add to the arrhythmic risk.
What this interaction means in plain words
Arformoterol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Nilotinib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta-2 agonist-related hypokalemia and tachycardia contributing.
What to do
Obtain a baseline ECG and repeat it periodically. Correct potassium and magnesium abnormalities and counsel the patient to report palpitations or fainting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Nilotinib?
MediHelp rates the interaction as moderate. Arformoterol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib has a boxed warning for QT prolongation and sudden death. Arformoterol, a long-acting beta-agonist, can prolong the QTc and lower potassium, which could add to the arrhythmic risk.
How serious is the interaction between Arformoterol and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it periodically. Correct potassium and magnesium abnormalities and counsel the patient to report palpitations or fainting.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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