Drug interactions
Arformoterol + Nortriptyline
Severity: Moderate
Arformoterol and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of long-acting beta-agonists such as arformoterol, causing tachycardia, QT prolongation and arrhythmias. Labeling advises extra caution with tricyclics.
What this interaction means in plain words
Arformoterol and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive QT prolongation and enhanced adrenergic stimulation via tricyclic blockade of norepinephrine reuptake.
What to do
Monitor heart rate, blood pressure and ECG, especially in patients with cardiac disease. Consider an alternative bronchodilator or antidepressant if arrhythmia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Nortriptyline?
MediHelp rates the interaction as moderate. Arformoterol and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of long-acting beta-agonists such as arformoterol, causing tachycardia, QT prolongation and arrhythmias. Labeling advises extra caution with tricyclics.
How serious is the interaction between Arformoterol and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, especially in patients with cardiac disease. Consider an alternative bronchodilator or antidepressant if arrhythmia develops.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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