Drug interactions
Arformoterol + Phenelzine
Severity: Major
Arformoterol and Phenelzine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAOIs may potentiate the cardiovascular effects of long-acting beta-agonists, including QT prolongation, arrhythmia and blood pressure changes. Labeling advises extreme caution during or within 2 weeks of MAOI use.
What this interaction means in plain words
Arformoterol and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arformoterol belongs to Respiratory; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition amplifies adrenergic cardiovascular effects of the beta-agonist, an effect established mainly by labeling and theory.
What to do
Monitor heart rate, blood pressure and ECG, and consider an alternative bronchodilator class if cardiovascular symptoms occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Phenelzine?
MediHelp rates the interaction as major. Arformoterol and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAOIs may potentiate the cardiovascular effects of long-acting beta-agonists, including QT prolongation, arrhythmia and blood pressure changes. Labeling advises extreme caution during or within 2 weeks of MAOI use.
How serious is the interaction between Arformoterol and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and consider an alternative bronchodilator class if cardiovascular symptoms occur.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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