Drug reference
phenelzine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (MAOIs)
Mechanism of action
Nonselective monoamine oxidase inhibitor; may inhibit the enzyme monoamine oxidase, which is responsible for the breakdown of dopamine, serotonin, epinephrine, and norepinephrine, in turn causing an increase in endogenous concentrations of these neurotransmitters.
Common side effects
- Asthenia
- Dizziness
- Drowsiness
- Headache
- Fatigue
- Orthostatic hypotension
- Hyperreflexia
Known interactions (43)
- amitriptyline + phenelzine Contraindicated
- atomoxetine + phenelzine Contraindicated
- brimonidine + phenelzine Contraindicated
- bupropion + phenelzine Contraindicated
- bupropion-naltrexone + phenelzine Contraindicated
- buspirone + phenelzine Contraindicated
- carbamazepine + phenelzine Contraindicated
- carbidopa-entacapone-levodopa + phenelzine Contraindicated
- carbidopa-levodopa + phenelzine Contraindicated
- citalopram + phenelzine Contraindicated
- clomipramine + phenelzine Contraindicated
- cyclobenzaprine + phenelzine Contraindicated
- cyproheptadine + phenelzine Contraindicated
- desipramine + phenelzine Contraindicated
- desvenlafaxine + phenelzine Contraindicated
- dextroamphetamine + phenelzine Contraindicated
- dextromethorphan + phenelzine Contraindicated
- dosulepin + phenelzine Contraindicated
- duloxetine + phenelzine Contraindicated
- entacapone + phenelzine Contraindicated
- epinephrine + phenelzine Contraindicated
- escitalopram + phenelzine Contraindicated
- fentanyl + phenelzine Contraindicated
- fluoxetine + phenelzine Contraindicated
- fluvoxamine + phenelzine Contraindicated
- imipramine + phenelzine Contraindicated
- isocarboxazid + phenelzine Contraindicated
- meperidine + phenelzine Contraindicated
- phenelzine + sumatriptan Contraindicated
- phenelzine + tramadol Contraindicated
- adrenaline-articaine + phenelzine Major
- almotriptan + phenelzine Major
- budesonide-formoterol + phenelzine Major
- dobutamine + phenelzine Major
- dopamine + phenelzine Major
- eletriptan + phenelzine Major
- fluticasone-salmeterol + phenelzine Major
- formoterol + phenelzine Major
- frovatriptan + phenelzine Major
- ipratropium-salbutamol + phenelzine Major
- isoproterenol + phenelzine Major
- armodafinil + phenelzine Moderate
- caffeine + phenelzine Moderate
Related conditions
Frequently asked questions
What drug class is phenelzine?
phenelzine belongs to: Central Nervous System.
How does phenelzine work?
Nonselective monoamine oxidase inhibitor; may inhibit the enzyme monoamine oxidase, which is responsible for the breakdown of dopamine, serotonin, epinephrine, and norepinephrine, in turn causing an increase in endogenous concentrations of these neurotransmitters.
What are the common side effects of phenelzine?
Asthenia, Dizziness, Drowsiness, Headache, Fatigue, Orthostatic hypotension, Hyperreflexia
Which drugs interact with phenelzine?
amitriptyline, atomoxetine, brimonidine, bupropion, bupropion-naltrexone, buspirone, carbamazepine, carbidopa-entacapone-levodopa, carbidopa-levodopa, citalopram, clomipramine, cyclobenzaprine, cyproheptadine, desipramine, desvenlafaxine
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