Drug interactions
Arformoterol + Salbutamol
Severity: Moderate
Arformoterol and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two beta-2 agonists given together add to each other's effects, including tachycardia, tremor, raised blood pressure, hypokalemia and arrhythmia risk. Duplicate therapy offers little extra bronchodilation and increases adverse cardiovascular effects.
What this interaction means in plain words
Arformoterol and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Salbutamol belongs to Respiratory.
Why it happens
Additive beta-2 adrenergic receptor stimulation causing cardiac stimulation and intracellular potassium shift.
What to do
Use salbutamol only as occasional rescue therapy with arformoterol maintenance; monitor heart rate and potassium if frequent rescue doses are needed, and review the regimen if so.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Salbutamol?
MediHelp rates the interaction as moderate. Arformoterol and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two beta-2 agonists given together add to each other's effects, including tachycardia, tremor, raised blood pressure, hypokalemia and arrhythmia risk. Duplicate therapy offers little extra bronchodilation and increases adverse cardiovascular effects.
How serious is the interaction between Arformoterol and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use salbutamol only as occasional rescue therapy with arformoterol maintenance; monitor heart rate and potassium if frequent rescue doses are needed, and review the regimen if so.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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