Drug interactions
Carvedilol + Salbutamol
Severity: Major
Carvedilol and Salbutamol: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol is a non-selective beta-blocker that can antagonise salbutamol and precipitate severe bronchospasm in patients with asthma or COPD. The bronchodilator response to salbutamol may be markedly reduced.
What this interaction means in plain words
Carvedilol and Salbutamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carvedilol belongs to Cardiovascular; Salbutamol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism via non-selective beta-1 and beta-2 receptor blockade.
What to do
Avoid carvedilol in patients with asthma; in COPD or heart failure consider a cardioselective alternative and monitor respiratory function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Salbutamol
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Salbutamol?
MediHelp rates the interaction as major. Carvedilol and Salbutamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carvedilol is a non-selective beta-blocker that can antagonise salbutamol and precipitate severe bronchospasm in patients with asthma or COPD. The bronchodilator response to salbutamol may be markedly reduced.
How serious is the interaction between Carvedilol and Salbutamol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid carvedilol in patients with asthma; in COPD or heart failure consider a cardioselective alternative and monitor respiratory function closely.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Droperidol, Fexinidazole. The full list is on the Salbutamol page.
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