Drug interactions
Arformoterol + Spironolactone
Severity: Minor
Arformoterol and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arformoterol can lower serum potassium through beta-2 mediated cellular uptake, whereas spironolactone raises it. The net effect is unpredictable and usually small.
What this interaction means in plain words
Arformoterol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Arformoterol belongs to Respiratory; Spironolactone belongs to Cardiovascular.
Why it happens
Beta-2 agonist-induced intracellular potassium shift opposing spironolactone's potassium retention.
What to do
Monitor serum potassium in patients with unstable respiratory disease or other hypokalemia risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Spironolactone?
MediHelp rates the interaction as minor. Arformoterol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Arformoterol can lower serum potassium through beta-2 mediated cellular uptake, whereas spironolactone raises it. The net effect is unpredictable and usually small.
How serious is the interaction between Arformoterol and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with unstable respiratory disease or other hypokalemia risk factors.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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