Drug interactions
Arformoterol + Umeclidinium-vilanterol
Severity: Major
Arformoterol and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are long-acting beta-2 agonists, so using them together duplicates therapy. This increases the risk of tachycardia, arrhythmia, tremor, hypokalemia and QT prolongation without added benefit.
What this interaction means in plain words
Arformoterol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arformoterol belongs to Respiratory; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Duplicate beta-2 agonist pharmacology with additive cardiovascular and metabolic effects.
What to do
Avoid concurrent use of two long-acting beta-agonists and use only one. Monitor heart rate and potassium if a switch is under way.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Arformoterol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are long-acting beta-2 agonists, so using them together duplicates therapy. This increases the risk of tachycardia, arrhythmia, tremor, hypokalemia and QT prolongation without added benefit.
How serious is the interaction between Arformoterol and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two long-acting beta-agonists and use only one. Monitor heart rate and potassium if a switch is under way.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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